Head Neck. 2017 Apr 28. doi: 10.1002/hed.24780. [Epub ahead of print]

Barry CP1,2,3,4, Wong D1, Clark JR2,5, Shaw RJ1,6, Gupta R3,7, Magennis P1, Triantafyllou A1, Gao K2, Brown JS1,6.

Author information:

1 Liverpool Head and Neck Cancer Unit, Aintree University Hospital, Liverpool, Merseyside, United Kingdom.

2 Sydney Head and Neck Cancer Institute, Chris O Brien Lifehouse, Sydney, New South Wales, Australia.

3 National Maxillofacial Unit, St. James’s Hospital, Dublin, Ireland.

4 Dublin Dental University Hospital, Dublin, Ireland.

5 Central Clinical School, University of Sydney, Sydney, New South Wales, Australia.

6 Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, Merseyside, United Kingdom.

7 Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.



The purpose of this study was to determine the effect of postoperative radiotherapy (PORT) on recurrence and survival in patients with oral squamous cell carcinoma (OSCC) of intermediate recurrence risk.


Intermediate risk patients, defined as pT1, pT2, pN0, or pN1 with at least one adverse pathological feature (eg, lymphovascular/perineural invasion), were identified from the head and neck databases of the Liverpool Head and Neck Cancer Unit and the Sydney Head and Neck Cancer Institute. Patients who received surgery and PORT were case matched with patients treated by surgery alone based on pN, pT, margins, and pathological features.


Ninety patients were matched into 45 pairs. There was significant improvement (P = .039) in locoregional control with PORT (84%) compared with surgery alone (60%), which was concentrated in the pN1 subgroup (P = .036), but not the pN0 subgroup (P = .331).


PORT significantly improves locoregional control for intermediate risk OSCC.

© 2017 Wiley Periodicals, Inc.

PMID: 28452199

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