Aintree – A Longitudinal Modelling Study Estimates Acute Symptoms of Community Acquired Pneumonia Recover to Baseline by 10 Days

Authors:  Wootton DG, Dickinson L, Pertinez H, Court J, Eneje O, Keogan L, Macfarlane L, Wilks S, Gallagher J, Woodhead M, Gordon SB, Diggle PJ.

Source: Eur Respir J. 2017 Jun 15;49(6). pii: 1602170.

doi: 10.1183/13993003.02170-2016. Print 2017 Jun.

PMID: 28619956 [PubMed – in process]

Aintree – Switching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician

Authors: Moots R, Azevedo V, Coindreau JL, Dörner T, Mahgoub E, Mysler E, Scheinberg M, Marshall L.

Source: Curr Rheumatol Rep. 2017 Jun;19(6):37.

doi: 10.1007/s11926-017-0658-4. Review.

PMID: 28623625 [PubMed – in process]


Walton Centre – Radiofrequency Electrode Failure During a Percutaneous Cervical Cordotomy: Standard Testing Software Algorithms of Modern RF Machines May Fail to Detect Faults

Author(s): Gupta M.; Sharma M.L.

Source: Pain Medicine (United States); 2017; vol. 18 (no. 3); p. 566-568

Publication Date: 2017

Publication Type(s): Letter

Database: EMBASE

Walton Centre – The Use of Mobile Applications to Support Self-Management for People with Asthma: A Systematic Review of Controlled Studies to Identify Features Associated with Clinical Effectiveness and Adherence

Author(s): Hui C.Y.; Jackson T.; Pinnock H.; Walton R.; McKinstry B.; Parker R.

Source: Journal of the American Medical Informatics Association; 2017; vol. 24 (no. 3); p. 619-632

Publication Date: 2017

Publication Type(s): Review

Abstract:Objectives: Telehealth is promoted as a strategy to support self-management of long-term conditions. The aim of this systematic review is to identify which information and communication technology features implemented in mobile apps to support asthma self-management are associated with adoption, adherence to usage, and clinical effectiveness. Methods: We systematically searched 9 databases, scanned reference lists, and undertook manual searches (January 2000 to April 2016). We include randomized controlled trials (RCTs) and quasiexperimental studies with adults. All eligible papers were assessed for quality, and we extracted data on the features included, health-related outcomes (asthma control, exacerbation rate), process/intermediate outcomes (adherence to monitoring or treatment, self-efficacy), and level of adoption of and adherence to use of technology. Metaanalysis and narrative synthesis were used. Results: We included 12 RCTs employing a range of technologies. A meta-analysis (n = 3) showed improved asthma control (mean difference -0.25 [95% CI, -0.37 to -0.12]). Included studies incorporated 10 features grouped into 7 categories (education, monitoring/electronic diary, action plans, medication reminders/prompts, facilitating professional support, raising patient awareness of asthma control, and decision support for professionals). The most successful interventions included multiple features, but effects on health-related outcomes were inconsistent. No studies explicitly reported adoption of and adherence to the technology system. Conclusion: Meta-analysis of data from 3 trials showed improved asthma control, though overall the clinical effectiveness of apps, typically incorporating multiple features, varied. Further studies are needed to identify the features that are associated with adoption of and adherence to use of the mobile app and those that improve health outcomes.

Copyright © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved.

Database: EMBASE

Walton Centre – Female Hormonal Exposures and Neuromyelitis Optica Symptom Onset in a Multicenter Study

Author(s): Bove R.; Chitnis T.; Mateen F.J.; Klawiter E.C.; Elsone L.; Mutch K.; Jacob A.; Alvarez E.; Cross A.H.; Borisow N.; Ruprecht K.; Paul F.; Cortez M.M.; Tobyne S.; Mealy M.A.; Levy M.; Buckle G.; Weinshenker B.; Wingerchuk D.M.

Source: Neurology: Neuroimmunology and NeuroInflammation; 2017; vol. 4 (no. 3)

Publication Date: 2017

Publication Type(s): Article

Abstract:Objective: To study the association between hormonal exposures and disease onset in a cohort of women with neuromyelitis optica spectrum disorder (NMOSD). Methods: Reproductive history and hormone use were assessed using a standardized reproductivesurveyadministered towomen with NMOSD (82% aquaporin-4antibody positive) at 8clinical centers. Using multivariable regression, we examined the association between reproductive exposures and age at first symptom onset (FS). Results: Among 217 respondents, the mean age at menarche was 12.8 years (SD 1.7). The mean number of pregnancies was 2.1 (SD 1.6), including 0.3 (SD 0.7) occurring after onset of NMOSD symptoms. In the 117 participants who were postmenopausal at the time of the questionnaire, 70% reported natural menopause (mean age: 48.9 years [SD 3.9]); fewer than 30% reported systemic hormone therapy (HT) use. Mean FS age was 40.1 years (SD 14.2). Ever-use of systemic hormonal contraceptives (HC) was marginally associated with earlier FS (39 vs 43 years, p 5 0.05). Because HC use may decrease parity, when we included both variables in the model, the association between HC use and FS age became more significant (estimate 5 2.7, p 5 0.007). Among postmenopausal participants, 24% reported NMOSD onset within 2 years of (before or after) menopause. Among these participants, there was no association between age at menopause or HT use and age at NMOSD onset. Conclusions: Overall, age at NMOSD onset did not show a strong relationship with endogenous hormonal exposures. An earlier onset age did appear to be marginally associated with systemic HC exposure, an association that requires confirmation in future studies.Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Database: EMBASE

Walton Centre – ANO Guidelines for the Diagnosis and Treatment of Meningiomas.

Authors: Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, von Deimling A, Stavrinou P, Lefranc F, Lund-Johansen M, Moyal EC, Brandsma D, Henriksson R, Soffietti R, Weller M.

Source: Lancet Oncol. 2016 Sep;17(9):e383-91.

doi: 10.1016/S1470-2045(16)30321-7. Epub 2016 Aug 30. Review.

PMID: 27599143 [PubMed – indexed for MEDLINE]


Walton Centre – Spontaneous Recovery of Memory Functions in an Untreated Case of Anti NMDAR Encephalitis – A Reason to Maintain Hope

Authors: McIvor K, Moore P.

Source: Clin Neuropsychol. 2017 Jan;31(1):289-300.

doi: 10.1080/13854046.2016.1245358. Epub 2016 Oct 20.

PMID: 27762163 [PubMed – indexed for MEDLINE]