Author(s): Franceschini P.; Hussain M.; Sunderland G.; Tambirajoo K.; Byrne P.; Alusi S.; Farah J.; Eldridge P.

Source: British Journal of Neurosurgery; 2018; vol. 32 (no. 1); p. 78

Publication Date: 2018

Publication Type(s): Conference Abstract

Abstract:Objectives: In this study we review the outcomes following Deep Brain Stimulation for Parkinson’s disease. The systems were implanted in a single centre over an 8 year period. Design: UPDRS, EQ-5D, and PDQ-39 outcome measures were collected prior to implantation and at 1year. Methods: The prospectively collected data was analysed using SPSS software. Results: 108 patients Parkinson’s disease had deep brain stimulators inserted from 2009 to 2016 with a mean age of 59y (36-73). 102 were STN and 6 ZI target. The mean PD-39 score pre DBS was 65.08 and post DBS 53.64 (p<0.01 Paired T-test). The EQ-5D score showed a reported improvement in self-care in 32% of patients but only 2% reported improvement in mobility. The UPDRS was improved in all parameters except UPDRS-1. 82% of patients reported improvements in UPDRS-3 and UPDRS-4. 4 systems were explanted at 6months, no mortality associated with the procedure. All patients had post op imaging with no evidence of intracranial haematoma. Conclusions: This is a large series in a single centre showing that deep brain stimulation for Parkinson’s disease is safe and effective treatment. The results show that the greatest effects are in motor function and improvements in off states and fluctuations in symptoms. The overall quality of life has been shown to significantly improve post DBS implantation.

Database: EMBASE