Author(s): Pullicino R.; Radon M.; Biswas S.; Bhojak M.; Das K.
Source: Clinical Neuroradiology; Mar 2018 ; p. 1-11
Publication Date: Mar 2018
Publication Type(s): Article In Press
Available at Clinical Neuroradiology – from SpringerLink – Medicine
Abstract:Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.
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