Author(s): Spina G.; Den Brinker A.C.; Spruit M.A.; Mesquita R.; Wouters E.F.M.; Alison J.; McKeough Z.J.; Benzo R.P.; Calverley P.M.A.; Clarenbach C.F.; Van Gestel A.J.R.; Kohler M.; Costello R.W.; Donaire-Gonzalez D.; Garcia-Aymerich J.; Durr S.; Leuppi J.D.; Miedinger D.; Zogg S.; Gramm M.; Kirsten A.M.; Magnussen H.; Waschki B.; Watz H.; Hernandes N.A.; Pitta F.; Hill K.; Hopkinson N.S.; Man W.D.-C.; Jarreta D.; Maltais F.; Singh S.J.; Smeenk F.W.J.M.; Tal-Singer R.; Vagaggini B.
Source: Thorax; Aug 2017; vol. 72 (no. 8); p. 694-701
Publication Date: Aug 2017
Publication Type(s): Article
Available in full text at Thorax – from Highwire Press
Abstract:Background: Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied. Aims: To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity. Methods: Data were analysed from 932 patients with COPD (66% male, 66.4+/-8.3 years, FEV 1 % predicted=50.8+/-20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients’ subsequent daytime physical activity. Results: Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts >=225 min, sleep efficiency >=91% and time spent awake after sleep onset
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