Author(s): Ouyang J.; Cuthbertson D.J.; Hardy R.; Brown M.; Helliwell T.; Gurnell M.
Source: Journal of Human Hypertension; Jul 2017; vol. 31 (no. 7); p. 483-484
Publication Date: Jul 2017
Publication Type(s): Article
Abstract:Primary hyperaldosteronism, characterised by hypertension and hypokalaemia, is a syndrome caused by aldosterone excess most commonly from either a unilateral aldosteroneproducing adenoma or bilateral adrenal hyperplasia. Subtype classification can be challenging with cross-sectional imaging and even with interventional radiological techniques such as adrenal venous sampling. Imaging with 11C-metomidate positron emission tomography-computed tomography (PETCT) is an emerging tool that facilitates functional characterization and potentially successful surgical intervention of aldosterone-producing adenomas. This technique has highlighted that, although unilateral adenomas and bilateral hyperplasia represent opposite ends of the disease spectrum, a relatively common intermediate phenotype exists of unilateral/bilateral multinodular disease.
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Database: EMBASE